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Product Description

Berberine Hydrochloride is a natural isoquinoline alkaloid extracted from various medicinal plants, mainly composed of berberine. Through hydrochloride processing, it achieves high water solubility and enhanced bioavailability. It is a widely studied natural bioactive compound with pharmacological activities including antibacterial, anti-inflammatory, blood glucose and lipid regulation, cardiovascular protection, and modulation of intestinal microbiota.

Chemical and Physical Properties

Item	Specification
Appearance	Yellow to yellow-brown crystalline powder
Odor / Taste	Characteristic bitter taste
Solubility	Soluble in water, methanol, ethanol; slightly soluble in acetone; practically insoluble in chloroform and ether
Assay (HPLC)	≥97%
Loss on Drying	≤5.0%
Ash	≤0.5%
Heavy Metals	≤10 ppm
Total Plate Count	<1000 CFU/g
Yeast & Mold	<100 CFU/g
Escherichia coli	Not detected

Functions and Biological Activities

Antibacterial Activity: Inhibits Gram-positive and Gram-negative bacteria by interfering with DNA replication and protein synthesis.

Anti-inflammatory: Suppresses the release of inflammatory cytokines such as TNF-α and IL-6, reducing inflammation.

Blood Glucose Regulation: Activates AMPK signaling pathway to improve insulin sensitivity and glucose metabolism, supporting diabetes management.

Blood Lipid Regulation: Reduces total cholesterol, triglycerides, and LDL cholesterol, improving lipid profile.

Cardiovascular Protection: Exerts vasodilatory effects, improves microcirculation, inhibits atherosclerosis, and has anti-arrhythmic properties.

Gut Microbiota Modulation: Inhibits harmful bacteria and promotes beneficial bacteria growth, maintaining intestinal microbiota balance.

Other Effects: Antioxidant, anticancer, hepatoprotective, neuroprotective, and potential benefits for metabolic syndrome.

Main Application

Field	Typical Uses
Pharmaceuticals	Raw material or intermediate for antibacterial, anti-diabetic, lipid-lowering, anti-inflammatory, and cardiovascular protective drugs
Dietary Supplements	Functional supplements for blood glucose, blood lipid, and gut health support
Cosmetics	Anti-inflammatory or antioxidant active ingredients in topical formulations
Research Reagents	Pharmacological, toxicological, and preclinical research material

Market and Regulatory Information

Regulatory Status: Berberine Hydrochloride is recognized as a natural bioactive compound. Its use as a pharmaceutical or functional ingredient is regulated by country-specific laws, including dosage limits and applications.

Export Compliance: Certificates and documents available: COA, MSDS, TDS, HPLC chromatograms, and component analysis reports to meet import requirements in various countries.